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论文题目: A malectin-like receptor kinase regulates cell death and pattern-triggered immunity in soybean
英文论文题目: A malectin-like receptor kinase regulates cell death and pattern-triggered immunity in soybean
第一作者: Wang, Dongmei
英文第一作者: Wang, Dongmei
联系作者: 冯献忠,Dou, Daolong
英文联系作者: X. Z. Feng,D. L. Dou
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发表年度: 2020
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Plant cells can sense conserved molecular patterns through pattern recognition receptors (PRRs) and initiate pattern-triggered immunity (PTI). Details of thePTIsignaling network are starting to be uncovered in Arabidopsis, but are still poorly understood in other species, including soybean (Glycine max). In this study, we perform a forward genetic screen for autoimmunity-relatedlesion mimic mutants(lmms) in soybean and identify two allelic mutants, which carry mutations inGlyma.13G054400, encoding a malectin-like receptor kinase (RK). The mutants exhibit enhanced resistance to both bacterial and oomycete pathogens, as well as elevatedROSproduction upon treatment with the bacterial pattern flg22. Overexpression ofGmLMM1gene inNicotiana benthamianaseverely suppresses flg22-triggeredROSproduction and oomycete patternXEG1-induced cell death. We further show that GmLMM1 interacts with the flg22 receptorFLS2 and its co-receptorBAK1 to negatively regulate flg22-induced complex formation between them. Our study identifies an important component inPTIregulation and reveals that GmLMM1 acts as a molecular switch to control an appropriate immune activation, which may also be adapted to otherPRR-mediated immune signaling in soybean.

英文摘要:

Plant cells can sense conserved molecular patterns through pattern recognition receptors (PRRs) and initiate pattern-triggered immunity (PTI). Details of thePTIsignaling network are starting to be uncovered in Arabidopsis, but are still poorly understood in other species, including soybean (Glycine max). In this study, we perform a forward genetic screen for autoimmunity-relatedlesion mimic mutants(lmms) in soybean and identify two allelic mutants, which carry mutations inGlyma.13G054400, encoding a malectin-like receptor kinase (RK). The mutants exhibit enhanced resistance to both bacterial and oomycete pathogens, as well as elevatedROSproduction upon treatment with the bacterial pattern flg22. Overexpression ofGmLMM1gene inNicotiana benthamianaseverely suppresses flg22-triggeredROSproduction and oomycete patternXEG1-induced cell death. We further show that GmLMM1 interacts with the flg22 receptorFLS2 and its co-receptorBAK1 to negatively regulate flg22-induced complex formation between them. Our study identifies an important component inPTIregulation and reveals that GmLMM1 acts as a molecular switch to control an appropriate immune activation, which may also be adapted to otherPRR-mediated immune signaling in soybean.

刊物名称: Embo Reports
英文刊物名称: Embo Reports
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参与作者: D. M. Wang, X. X. Liang, Y. Z. Bao, S. X. Yang, X. Zhang, H. Yu, Q. Zhang, G. Y. Xu, X. Z. Feng and D. L. Dou
英文参与作者: D. M. Wang, X. X. Liang, Y. Z. Bao, S. X. Yang, X. Zhang, H. Yu, Q. Zhang, G. Y. Xu, X. Z. Feng and D. L. Dou